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| Joan Crawford | Louise Howell Graham |
| Van Heflin | David Sutton |
| Raymond Massey | Dean Graham |
| Geraldine Brooks | Carol Graham |
| Stanley Ridges | Dr. Harvey Williard |
| John Ridgely | Lt. Harker |
| Nana Bryant | Bit Part (uncredited) |
| Moroni Olsen | Dr. Ames |
| Erskine Sanford | Dr. Max Sherman |
| Gerald Perreau | Wynn Graham |
| Isabel Withers | Nurse Rosen |
| Lisa Golm | Elsie, the Maid |
| Douglas Kennedy | Assistant District Attorney |
| Monte Blue | Norris, the Caretaker |
| Don McGuire | Dr. Craig |
| Rory Mallinson | Coroner's Assistant |
| Clifton Young | Intern |
| Griff Barnett | Coroner |
| Ralph Dunn | Cable Car Motorman (uncredited) |
| Max Wagner | Man in Cafe (uncredited) |
| Dick Bartell | Man in Cafe (uncredited) |
| Frank Marlowe | Cafe Proprietor (uncredited) |
| Rose Plummer | Woman in Cafe (uncredited) |
After collapsing, disoriented, in a Los Angeles diner, Louise recounts the events of her life to a psychiatrist. While working as a nurse for the wife of wealthy Dean Graham, she falls in love with the Grahams' neighbor, David, who rejects her affection. Following the death of Dean's wife, Louise becomes the new Mrs. Graham, but her dangerous fixation on David continues. She grows increasingly unstable as her obsession leads to madness and violence.
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