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| Gillian Anderson | Meredith |
| Angelina Jolie | Joan |
| Madeleine Stowe | Gracie |
| Anthony Edwards | Roger |
| Ryan Phillippe | Keenan |
| Gena Rowlands | Hannah |
| Sean Connery | Paul |
| Dennis Quaid | Hugh |
| Ellen Burstyn | Mildred |
| Jay Mohr | Mark |
| Jon Stewart | Trent |
| Patricia Clarkson | Allison |
| Nastassja Kinski | The Lawyer (uncredited) |
| April Grace | Valery |
| Alec Mapa | Lana |
| Jeremy Sisto | Malcolm (uncredited) |
| Matt Malloy | Desk Clerk |
| Christian Mills | Phillip |
| Kellie Waymire | Jane |
| Tim Halligan | Cook Show Director |
| Michael Emerson | Bosco |
| David Clennon | Martin (uncredited) |
| Amanda Peet | Amber |
| David Ferguson | Drag Queen |
| Joel McCrary | Drag Bar Bartender |
| Worthie Meacham | Second Drag Queen |
| Michael Buchman Silver | Max |
| Hal Landon Jr. | Actor 'Commissioner' |
| Marc Allen Lewis | Actor 'Harpagon' |
| Ron Boussom | Actor 'Jacques' |
The lives and loves of three women are examined, along with a married couple's enduring relationship.
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