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| Seth Rogen | Dale Denton |
| James Franco | Saul Silver |
| Gary Cole | Ted Jones |
| Rosie Perez | Carol/Female Cop |
| Danny R. McBride | Red |
| Kevin Corrigan | Budlofsky |
| Craig Robinson | Matheson |
| Amber Heard | Angie Anderson |
| Ed Begley | Robert |
| Nora Dunn | Shannon |
| Bobby Lee | Bobby |
| James Remar | Gen. Bratt |
Stoner Dale Denton's enjoyment of a rare strain of marijuana may prove fatal when he drops his roach in a panic after witnessing a murder. Upon learning that the fancy weed can be traced back to them, Dale and his dealer go on the lam, with a dangerous drug lord and crooked cop hot on their heels.
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