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| Katie Holmes | April Burns |
| Patricia Clarkson | Joy Burns |
| Oliver Platt | Jim Burns |
| Derek Luke | Bobby |
| Alison Pill | Beth Burns |
| John Gallagher Jr. | Timmy Burns |
| Alice Drummond | Grandma Dottie |
| Sean Hayes | Wayne |
| Sisqó | Latrell |
| Lillias White | Evette |
| Isiah Whitlock Jr. | Eugene |
Quirky and rebellious April Burns lives with her boyfriend in a low-rent New York City apartment miles away from her emotionally distant family. But when she discovers that her mother has a fatal form of breast cancer, she invites the clan to her place for Thanksgiving. While her father struggles to drive her family into the city, April -- an inexperienced cook -- runs into kitchen trouble and must ask a neighbor for help.
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