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| Benjamin Bratt | Miguel Piñero |
| Giancarlo Esposito | Miguel Algarin |
| Talisa Soto | Sugar |
| Nelson Vasquez | Tito |
| Michael Irby | Reinaldo Povod |
| Michael Wright | Edgar |
| Rita Moreno | Miguel's Mother |
| Jaime Sanchez | Miguel's Father |
| Rome Neal | Jake |
| Mandy Patinkin | Joseph Papp |
| Oscar Colon | Bodega Man |
| Miriam Cruz | Bodega Woman |
| Sophia Domoulin | Shooting Gallery Woman |
| Robert Klein | Doctor |
| Gilbert Callazo | Miguel (as teen) |
| Samuel Bruce Campbell | Short Eyes Cop |
| Loraine Velez | Tutu |
| Griffin Dunne | Agent |
| Fisher Stevens | Public Theatre Cashier |
| Ray Santiago | Willie |
| Vanessa Del Sol | Heist Woman |
| Amiri Baraka | Himself |
Poet, playwright and actor Miguel Piñero spends time in jail for theft and drug dealing.
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