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| Gena Rowlands | Ivy |
| Tony Shalhoub | Misha Vilyenkov |
| Cheech Marin | Ignacio |
| Bruce Davison | Dr. Reingold |
| Jay Mohr | Benny/Voice of Paulie |
| Trini Alvarado | Adult Marie Alweather |
| Buddy Hackett | Artie |
| Hallie Kate Eisenberg | Marie Alweather |
| Matt Craven | Warren Alweather |
| Bill Cobbs | Virgil the Janitor |
| Tia Texada | Ruby/Voice of Lupe |
| Laura Harrington | Lila Alweather |
A parrot at an animal research lab tells his life story to a janitor who tries to help him escape.
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