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| Milo Ventimiglia | Ted Grey |
| Michael Weston | Jake Gallo |
| Alyssa Milano | Gwen Williamson |
| Lauren Lee Smith | Juliette Bath |
| Johnny Whitworth | Griffin Cavenaugh |
| John de Lancie | Dr. Quentin Morris |
| Mei Melancon | Catherine Ivy |
| Keir O'Donnell | Ben Stravinsky |
| Buddy Lewis | Harper Johnson |
| Dan Callahan | Chip Bentwood |
| Larry Drake | Fat Bastard |
Medical student Ted Grey graduates at the top of his class and quickly joins an elite pathology program, whose top students invite Ted into their circle. There he uncovers a gruesome secret; they play a game in which they try to commit the perfect, undetectable murder.
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