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| Robin Williams | Hunter ``Patch'' Adams |
| Daniel London | Truman Schiff |
| Monica Potter | Corrine Fisher |
| Philip Seymour Hoffman | Mitch Roman |
| Bob Gunton | Dean Walcott |
| Josef Sommer | Dr. Eaton |
| Irma P. Hall | Joletta |
| Frances Lee McCain | Judy |
| Harve Presnell | Dean J.P. Anderson |
| Daniella Kuhn | Adelane |
| Jake Bowen | Bryan |
| Peter Coyote | Bill Davis |
| James Greene | Bile |
| Michael Jeter | Rudy |
| Harold Gould | Arthur Mendelson |
| Richard Kiley | Dr. Titan |
| Douglas Roberts | Larry Silver |
After struggling with depression in a mental hospital, Hunter ''Patch'' Adams decides he wants to become a doctor. He enrolls at Virginia Medical University but is disillusioned by the school's clinical perspective on patient care. With the aid of a wealthy friend, Adams opens his own medical clinic for those without insurance. He forms a deep bond with fellow medical student Carin Fisher before a tragedy causes Adams to re-evaluate his approach.
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