| Paul Rudd | Ned |
| Elizabeth Banks | Miranda |
| Zooey Deschanel | Natalie |
| Emily Mortimer | Liz |
| Kathryn Hahn | Janet |
| Steve Coogan | Dylan |
| Rashida Jones | Cindy |
| Hugh Dancy | Christian |
| Shirley Knight | Ilene |
| Adam Scott | Jeremy |
| T.J. Miller | Billy |
| Janet Montgomery | Arabella |
| Matthew Mindler | River |
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Easygoing, dimwitted slacker Ned Rochlin makes the biggest mistake of his so-far uninspired life when he sells some pot to a cop. Homeless and jobless upon his release from jail, Ned must prevail upon his three sisters for help. Though Ned himself is utterly without a shred of ambition or guile, it's a different story with his sisters, who find their carefully ordered lives thrown into chaos whenever he's around.
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