|Molly Shannon||Mrs. Boyd|
|Elena Franklin||Shane Detomello|
|Danny Murphy||Zookeeper Superintendent|
|David Hyde Pierce||Drix|
|William Shatner||The Mayor|
|Ron Howard||Tom Colonic|
A cutting-edge, live action/animated action adventure comedy about one white blood cell's race against the biological clock to hunt down and destroy a lethal new virus . Bill Murray stars as Frank, in whose body the action unfolds.