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| Cary Grant | Geoff Carter |
| Jean Arthur | Bonnie Lee |
| Rita Hayworth | Judith 'Judy' MacPherson |
| Richard Barthelmess | Barthelmess |
| Thomas Mitchell | Kid Dabb |
| Sig Ruman | John 'Dutchy' Van Reiter (as Sig Rumann) |
| Victor Kilian | Sparks (radioman) |
| John Carroll | Gent Shelton |
| Allyn Joslyn | Les Peters |
| Donald Barry | Tex Gordon, lookout |
| Noah Beery Jr. | Joe Souther |
| Milisa Sierra | Lily, Joe's girl |
| Lucio Villegas | Dr. Lagorio |
| Forbes Murray | Mr. Harkwright, mine operator (uncredited) |
| Cecilia Callejo | Felice Torras, Geoff's lady friend (uncredited) |
| Pat Flaherty | Mike, head mechanic |
| Pedro Regas | Pancho |
A sassy chorus girl falls in love with a seat-of-the-pants pilot in South America.
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