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| Jack Nicholson | Randle Patrick McMurphy |
| Louise Fletcher | Nurse Mildred Ratched |
| Brad Dourif | Billy Bibbit |
| William Redfield | Harding |
| Michael Berryman | Ellis, tall bald patient |
| Peter Brocco | Col. Matterson |
| Dean Brooks | Dr. John Spivey |
| Alonzo Brown | Miller |
| Scatman Crothers | Orderly Turkle |
| Danny DeVito | Martini |
| Christopher Lloyd | Taber |
| Nathan George | Attendant Washington |
| Sydney Lassick | Charlie Cheswick |
| Phil Roth | Woolsey |
| Vincent Schiavelli | Frederickson |
When Randle Patrick McMurphy gets transferred for evaluation from a prison farm to a mental institution, he assumes it will be a less restrictive environment. But the martinet Nurse Ratched runs the psychiatric ward with an iron fist, keeping her patients cowed through abuse, medication and sessions of electroconvulsive therapy. The battle of wills between the rebellious McMurphy and the inflexible Ratched soon affects all the ward's patients.
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