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| Jack Nicholson | Randle Patrick McMurphy |
| Louise Fletcher | Nurse Mildred Ratched |
| Brad Dourif | Billy Bibbit |
| William Redfield | Harding |
| Michael Berryman | Ellis, tall bald patient |
| Peter Brocco | Col. Matterson |
| Dean Brooks | Dr. John Spivey |
| Alonzo Brown | Miller |
| Scatman Crothers | Orderly Turkle |
| Danny DeVito | Martini |
| Christopher Lloyd | Taber |
| Nathan George | Attendant Washington |
| Sydney Lassick | Charlie Cheswick |
| Phil Roth | Woolsey |
| Vincent Schiavelli | Frederickson |
Mental patients follow Randle P. McMurphy, the social-misfit hero of Ken Kesey's novel.
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