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| Laurence Fishburne | 20/20 Mike |
| Titus Welliver | Torch |
| Eamonn Walker | Tony |
| Dominic Chianese Jr. | Freddie Nine Lives |
| Paul Calderone | Manny Rivera |
| Gregory Hines | Ruffhouse |
| Annabella Sciorra | Maxine |
| Michael Paul Chan | Buddha |
| Andres ``Dres'' Titus | Hector |
| Tiger Chen | Chino |
A gritty drama centered around brotherhood and friendship, ``Once in the Life'' is a realistic depiction of how everyday choices affect our path in life. It is a cautionary tale about making the wrong choices and the inevitable, tragic conclusion of an individual who is drawn to a life of crime - - once in the life, always in the life.
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