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| Luke Wilson | Mitch |
| Will Ferrell | Frank |
| Vince Vaughn | Beanie |
| Jeremy Piven | Gordon Pritchard |
| Ellen Pompeo | Nicole |
| Juliette Lewis | Heidi |
| Leah Remini | Lara |
| Perrey Reeves | Marissa |
| Craig Kilborn | Mark |
| Elisha Cuthbert | Darcie |
| Patrick Cranshaw | Joseph Palasky |
| Jerod Mixon | Weensie |
| Seann William Scott | Peppers |
| Harve Presnel | Mr. Springbrook |
| James Carville | Himself |
| Snoop ``Doggy'' Dogg | Himself |
| Warren G. | Himself |
Three friends try to recapture the fun of their college years by starting their own off-campus fraternity.
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