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| John Travolta | Charlie |
| Robin Williams | Dan |
| Kelly Preston | Vicki |
| Seth Green | Ralph |
| Matt Dillon | Yancy Devlin |
| Ella Bleu Travolta | Marley |
| Lori Loughlin | |
| Conner Rayburn | |
| Justin Long | Adam Devlin |
| Bernie Mac | Jimmy Lunchbox |
| Rita Wilson | Gloria Lawrence |
| Dax Shepard | Trent Rice |
While preparing for an important business deal, two bachelors become the unexpected caretakers of twin children. One debacle after another follows, as the two clueless men try to take care of both their business duties and the rambunctious siblings. Though their lives are turned upside-down, the men may just gain an understanding of what is really important in life.
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