|John Malkovich||Lennie Small|
|Gary Sinise||George Milton|
|Casey Siemaszko||Curley, Boss' Son|
|Sherilyn Fenn||Curley's Wife|
|John Terry||Slim, Team Leader|
|Joe Morton||Crooks, Stable Buck|
|Noble Willingham||The Boss|
Itinerant worker George reflects on the time he spent traveling with Lennie, a huge childlike man. The two men drift through California during the Great Depression, looking for work. After they find jobs on a ranch, Lennie develops an infatuation with the owner's daughter-in-law . However, when George and Lennie are handed an opportunity to own part of the ranch, Lennie's fascination with the beautiful woman threatens to destroy their dreams.