| John Malkovich | Lennie Small |
| Gary Sinise | George Milton |
| Ray Walston | Candy |
| Casey Siemaszko | Curley, Boss' Son |
| Sherilyn Fenn | Curley's Wife |
| John Terry | Slim, Team Leader |
| Richard Riehle | Carlson |
| Alexis Arquette | Whitt |
| Joe Morton | Crooks, Stable Buck |
| Noble Willingham | The Boss |
Migrant worker George protects his strong, simple-minded friend Lennie in 1930s California.
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