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| Daniel Day-Lewis | Guido Contini |
| Marion Cotillard | Luisa Contini |
| Penélope Cruz | Carla Albanese |
| Judi Dench | Liliane La Fleur |
| Nicole Kidman | Claudia Nardi |
| Kate Hudson | Stephanie Necrophuros |
| Sophia Loren | Mamma |
| Stacy Ferguson | Saraghina |
| Martina Stella | Donatella |
Famous film director Guido Contini grapples with epic crises in his personal and professional life. At the same time, he must strike a balance among the demands of the numerous women in his life, including his wife, his mistress, his confidant and others.
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