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| Kathy Baker | Camille |
| Amy Brenneman | Lorna |
| Elpidia Carrillo | Sandra |
| Glenn Close | Maggie |
| Stephen Dillane | Martin |
| Dakota Fanning | Maria |
| William Fichtner | Andrew |
| Lisa Gay Hamilton | Holly |
| Holly Hunter | Sonia |
| Jason Isaacs | Damian |
| Joe Mantegna | Richard |
| Ian McShane | Larry |
| Molly Parker | Lisa |
| Mary Kay Place | Alma Morgan |
| Sydney Tamiia Poitier | Vanessa |
| Aidan Quinn | Henry |
| Miguel Sandoval | Ron/Male Guard |
| Amanda Seyfried | Samantha |
| Sissy Spacek | Ruth |
| Robin Wright Penn | Diana |
Stories revolve around an unstable woman, a teen and her disabled father, former lovers, a cancer patient and a prisoner .
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