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| Jamie Bell | Smike |
| Jim Broadbent | Wackford Squeers |
| Tom Courtenay | Newman Noggs |
| Alan Cumming | Mr. Folair |
| Edward Fox | Sir Mulberry Hawk |
| Romola Garai | Kate Nickleby |
| Anne Hathaway | Madeline Bray |
| Barry Humphries | Mrs. Crummles |
| Charlie Hunnam | Nicholas Nickleby |
| Nathan Lane | Vincent Crummles |
| Christopher Plummer | Ralph Nickleby |
| Timothy Spall | Charles Cheeryble |
| Juliet Stevenson | Mrs. Squeers |
| Stella Gonet | Mrs. Nickleby |
| Gerard Horan | Ned Cheeryble |
| Bruce Cook | Little Wackford Squeers |
| Phil Davis | Brooker |
| Heather Goldenhersh | Fanny Squeers |
| William Ash | Frank |
| Kevin McKidd | John Browdie |
| Nicholas Rowe | Lord Verisopht |
| David Bradley | Bray |
| Helen Coker | Tilda |
| Sophie Thompson | Miss Lacreevy |
| Hugh Mitchell | Boy Nicholas Nickleby |
| Angus Wright | Mr. Pluck |
| Eileen Walsh | The Infant Phenomenon |
Left penniless after his father's death, a young man protects the rest of his family from his wicked uncle in 19th-century England.
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