|Margaret Sullavan||Cicely Tyler|
|James Stewart||Christopher Tyler|
|Ray Milland||Tommy Abbott|
|Grant Mitchell||Michael Jennings|
|Robert McWade||Frank Carteret|
|Anna Demetrio||Madame Donato|
Christopher and Cicely Tyler are newlyweds, but they're also career-driven; he's a young newspaper reporter, and she's an aspiring actress. When Christopher is sent to Rome, their relationship becomes strained, and their friend Tommy tries to move in on Cicely, who he secretly loves. Further complications arise when Cicely finds she is pregnant, and Christopher leaves his job for her, forcing them to juggle their personal and professional lives.