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| Peter Weller | Bill Lee |
| Judy Davis | Joan Frost/Joan Lee |
| Ian Holm | Tom Frost |
| Julian Sands | Yves Cloquet |
| Roy Scheider | Doctor Benway |
| Monique Mercure | Fadela |
| Nicholas Campbell | Hank |
| Robert Silverman | Hans |
| Joseph Scorsiani | Kiki |
Blank-faced bug killer Bill Lee and his dead-eyed wife, Joan, like to get high on Bill's pest poisons while lounging with Beat poet pals. After meeting the devilish Dr. Benway, Bill gets a drug made from a centipede. Upon indulging, he accidentally kills Joan, takes orders from his typewriter-turned-cockroach, ends up in a constantly mutating Mediterranean city and learns that his hip friends have published his work -- which he doesn't remember writing.
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