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| Hank Azaria | The Blue Raja |
| Janeane Garofalo | The Bowler |
| William H. Macy | The Shoveller |
| Kel Mitchell | The Invisible Boy |
| Paul Reubens | The Spleen |
| Ben Stiller | Mr. Furious |
| Wes Studi | The Sphinx |
| Greg Kinnear | Lance Hunt/Captain Amazing |
| Lena Olin | Dr. Annabel Leek |
| Geoffrey Rush | Casanova Frankenstein |
| Tom Waits | Dr. A. Heller |
| Eddie Izzard | Tony P. |
| Claire Forlani | Monica the Waitress |
| Ricky Jay | Victor Weems |
| Louise Lasser | Violet, The Blue Raja's Mom |
Aspiring superheroes band together to defeat a villain when real superhero Captain Amazing disappears.
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