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| Uma Thurman | Jenny/G-Girl |
| Luke Wilson | Matt |
| Anna Faris | Hannah |
| Rainn Wilson | Vaughn |
| Eddie Izzard | Prof. Bedlam/Barry |
| Wanda Sykes | Carla Dunkirk |
| Mike Iorio | Lenny |
| Stelio Savante | Leo |
| Mark Consuelos | Steve |
| Tara Thompson | Young Jenny |
| Kevin Townley | Young Barry |
A young man discovers that the beautiful but manipulative woman he is dating is really a superheroine known as G-Girl. After breaking up with her, he learns that ``hell hath no fury like a woman scorned'' as she unleashes her considerable powers against him.
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