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| Meryl Streep | Roberta Guaspari |
| Aidan Quinn | Brian Turner |
| Angela Bassett | Janet Williams |
| Cloris Leachman | Assunta Guaspari |
| Gloria Estefan | Isabel Vasquez |
| Josh Pais | Dennis Rausch |
| Jay O. Sanders | Dan Paxton |
| Charlie Hofheimer | Nick at 17 |
| Kieran Culkin | Lexi at 15 |
| Michael Angarano | Nick at 7 |
| Henry Dinhofer | Lexi at 5 |
| Isaac Stern | Himself |
| Itzhak Perlman | Himself |
| Arnold Steinhardt | Himself |
| Mark O'Connor | Himself |
| Michael Tree | Himself |
| Charles Veal Jr. | Himself |
| Karen Briggs | Herself |
| Sandra Park | Herself |
| Diane Monroe | Herself |
| Jonathan Feldman | Himself |
After being abandoned by her husband, depressed music teacher Roberta lands a job teaching violin to underprivileged children in Harlem, New York. Despite initial friction from school principal Janet Williams and the students, the program succeeds and attracts public recognition. After 10 years, however, the program is suddenly shut down following budget cuts -- and Roberta, together with Williams and her former pupils, works to hold a fund-raising concert.
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