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| Loren Dean | Dr. Mickey Mumford |
| Hope Davis | Sofie Crisp |
| Jason Lee | Skip Skipperton |
| Alfre Woodard | Lily |
| Mary McDonnell | Althea Brockett |
| Pruitt Taylor Vince | Henry A. Follett |
| Zooey Deschanel | Nessa Watkins |
| Martin Short | Lionel Dillard |
| David Paymer | Dr. Ernest Delbanco |
| Jane Adams | Dr. Phyllis Sheeler |
| Dana Ivey | Mrs. Crisp |
| Kevin Tighe | Mr. Crisp |
| Ted Danson | Jeremy Brockett |
| Jason Ritter | Martin Brockett |
| Elisabeth Moss | Katie Brockett |
| Kirk Fox | Gregory Heskin |
| Robert Stack | Unsolved mysteries host |
| Scott N. Stevens | Ben Crisp |
| Eddie Allen | Mr. Gilroy, State Certification Board |
| Rick Dial | Correctional Officer |
| Joy Carlin | Judge Otto |
| Helene Cardona | Candy Heskin |
| Priscilla Barnes | Landlady |
| Kelly Monaco | Marisa, the Landlady's Daughter |
| Steven Sennett | Young Pharmacist |
| Amanda Carlin | Clarinda Sue Begley, Mumford's Sister |
| Randall King | Revenue Officer McLure |
| Arell Blanton | Brother Timothy |
| Eddie McClintock | Unsolved Mysteries 'Mumford' |
| Molly Schaffer | Attractive Date |
A young man quits his IRS job and heads to a small town, where he poses as a psychologist and gives no-nonsense advice.
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