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| Kenneth Branagh | Seigneur Benedick |
| Emma Thompson | Beatrice |
| Denzel Washington | Don Pedro of Aragon |
| Keanu Reeves | Don John |
| Michael Keaton | Constable Dogberry |
| Robert Sean Leonard | Count Claudio of Florence |
| Richard Briers | Seigneur Leonato (Governor of Messina) |
| Kate Beckinsale | Hero |
| Gerard Horan | Borachio |
| Richard Clifford | Conrade |
| Brian Blessed | Seigneur Antonio |
| Patrick Doyle | Balthazar |
| Jimmy Yuill | Friar Francis |
| Imelda Staunton | Margaret |
| Phyllida Law | Ursula |
| Ben Elton | Headborough Verges |
| Edward Jewesbury | Sexton |
| Andy Hockley | George Seacole |
| Chris Barnes | Francis Seacole |
| Conrad Nelson | Hugh Oatcake |
| Alex Scott | The Boy |
| Alex Lowe | Messenger |
Shakespeare's Don Pedro pairs Benedick and Beatrice and woos Hero for Claudio around a lively Italian villa.
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