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| Brendan Fraser | Stu Miley |
| Bridget Fonda | Julie McElroy |
| Rose McGowan | Kitty |
| Whoopi Goldberg | Death |
| Chris Kattan | Organ Donor Stu |
| Dave Foley | Herb |
| Megan Mullally | Kimmy |
| Jamie Donovan | Reporter #1 |
| Amy Higgins | Clarissa |
| Allan Trautman | BBQ Pig |
| Owen Masterson | Jack the Ripper |
| Randall Bosley | Fred |
| Giancarlo Esposito | Hypnos |
| Arturo Gil | Rat Guard |
| Paul Guiles | Reporter #2 |
| Shawnee Free Jones | Lizzie Borden |
| Harry Jay Knowles | Lucky |
| Jason Kravits | Guest |
| Pons Maar | Lead Puppeteer |
| Skyler Marshall | Janitor |
| Mary Stein | Lulu |
| John Turturro | Monkeybone |
A comatose cartoonist lands in limbo while his simian alter ego takes over his body and escapes to the real world.
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