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| Sandra Bullock | Gracie Hart |
| Regina King | Sam Fuller |
| Enrique Murciano | Jeff Foreman |
| William Shatner | Stan Fields |
| Ernie Hudson | Harry McDonald |
| Heather Burns | Cheryl Frasier |
| Diedrich Bader | Joel Myers |
| Treat Williams | Walter Collins |
| Abraham Benrubi | Lou Steele |
| Nick Offerman | Karl Steele |
| Eileen Brennan | Carol Fields |
| Elisabeth Rohm | Janet McCarren |
| Molly Gottlieb | Priscilla |
| Regis Philbin | Himself |
| Joy Philbin | Herself |
| Marcelo Tubert | Roberto Fenice |
| Stephen Tobolowsky | Tom Abernathy |
| Dolly Parton | Herself |
| Lusia Strus | Janine |
| Leslie Grossman | Pam |
FBI agent Gracie Hart clashes with her superiors when she jumps in to save two kidnapped friends in Las Vegas.
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