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| Guy Pearce | Leonard Shelby |
| Carrie-Anne Moss | Natalie |
| Joe Pantoliano | Teddy |
| Mark Boone Junior | Burt |
| Stephen Tobolowsky | Sammy |
| Harriet Sansom Harris | Mrs. Jankis |
| Callum Keith Rennie | Dodd |
| Russ Fega | Waiter |
| Kimberly Campbell | Blonde |
| Larry Holden | Jimmy Grantz |
Leonard is tracking down the man who raped and murdered his wife. The difficulty, however, of locating his wife's killer is compounded by the fact that he suffers from a rare, untreatable form of memory loss. Although he can recall details of life before his accident, Leonard cannot remember what happened fifteen minutes ago, where he's going, or why.
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