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| Robert De Niro | Jack Byrnes |
| Ben Stiller | Greg Focker |
| Dustin Hoffman | Mr. Focker |
| Barbra Streisand | Mrs. Focker |
| Blythe Danner | Dina Byrnes |
| Teri Polo | Pam Byrnes |
| Tim Blake Nelson | Officer LeFlore |
| Alanna Ubach | Isabel Villalobos |
| Ray Santiago | Jorge Villalobos |
| Kali Rocha | Flight Attendant |
| Shelley Berman | Judge Ira |
| Owen Wilson | Kevin Rawley |
| Spencer Pickren | Little Jack 'L.J.' Byrnes |
| Bradley Pickren | Little Jack 'L.J.' Byrnes |
A man fears the worst when he accompanies his fiancee's uptight father and mother to meet his free-spirited mom and dad .
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