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| Meryl Streep | Lee |
| Leonardo DiCaprio | Hank |
| Diane Keaton | Bessie |
| Robert De Niro | Dr. Wally |
| Hume Cronyn | Marvin |
| Gwen Verdon | Ruth |
| Hal Scardino | Charlie |
| Dan Hedaya | Bob |
| Margo Martindale | Dr. Charlotte |
| Cynthia Nixon | Retirement Home Director |
Bessie and Lee are sisters who have remained apart for nearly 20 years due to radically different personalities and life paths. Bessie remained in Florida to care for their ill, bed-ridden father, and Lee moved to Ohio to marry and have a family. But Bessie's doctor has informed her she has leukemia and needs a bone marrow transplant. Bessie's prognosis and Lee's troubled son create an unexpected family reunion.
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