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| Jack Nicholson | President James Dale/Art Land |
| Glenn Close | First Lady Marsha Dale |
| Annette Bening | Barbara Land |
| Pierce Brosnan | Professor Donald Kessler |
| Danny DeVito | Rude Gambler |
| Martin Short | Press Secretary Jerry Ross |
| Sarah Jessica Parker | Nathalie Lake |
| Michael J. Fox | Jason Stone |
| Rod Steiger | General Decker |
| Tom Jones | Himself |
| Lukas Haas | Richie Norris |
| Natalie Portman | Taffy Dale |
| Jim Brown | Byron Williams |
| Lisa Marie | Martian Girl |
| Sylvia Sidney | Grandma Florence Norris |
| Christina Applegate | Sharona |
| Joe Don Baker | Richie's Dad |
| Pam Grier | Louise Williams |
| Paul Winfield | General Casey |
| Jack Black | Billy Glenn Norris |
| Brandon Hammond | Neville Williams |
| O-Lan Jones | Sue Ann Norris |
| Janice Rivera | Cindy |
| Ray J | Cedric Williams |
| Brian Haley | Mitch, Secret Service Agent |
| Jerzy Skolimowski | Dr. Zeigler |
| Timi Prulhiere | White House Tour Guide |
| Barbet Schroeder | Maurice, the French President |
Martians take delight in incinerating humans in director Tim Burton's sendup of 1950s sci-fi classics.
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