|William L. Petersen||FBI Agent Will Graham (as William Petersen)|
|Kim Greist||Molly Graham|
|Dennis Farina||FBI Section Chief Jack Crawford|
|Joan Allen||Reba McClane|
|Brian Cox||Dr. Hannibal Lecktor|
|Stephen Lang||Freddy Lounds|
|Tom Noonan||Francis Dollarhyde|
FBI criminal profiler Will Graham is called out of early retirement to assist on a serial murder case involving a killer known as the ''Tooth Fairy'' . Graham enlists the help of imprisoned serial killer -- and cannibal -- Dr. Hannibal Lecktor, who is the reason Graham took an early retirement. Soon, Graham and the FBI are entangled in a deadly cat-and-mouse game between the Tooth Fairy, Lecktor and an interfering journalist .