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| Jason Robards | Earl Partridge |
| Julianne Moore | Linda Partridge |
| Tom Cruise | Frank T.J. Mackey |
| Philip Seymour Hoffman | Phil Parma |
| John C. Reilly | Jim Kurring |
| Melora Walters | Claudia Wilson Gator |
| Jeremy Blackman | Stanley Spector |
| Michael Bowen | Rick Spector |
| William H. Macy | Donnie Smith (Quiz Kid) |
| Philip Baker Hall | Jimmy Gator |
| Melinda Dillon | Rose Gator |
| Emmanuel Johnson | Dixon |
| Michael Murphy | Alan Kligman, Esq. |
| Luis Guzman | Himself |
| April Grace | Gwenovier |
| Orlando Jones | Worm |
| Ricky Jay | Burt Ramsey/Prologue Narrator |
| Henry Gibson | Thurston Howell |
| Felicity Huffman | Cynthia |
| Alfred Molina | Solomon Solomon |
| Don McManus | Dr. Landon |
| Eileen Ryan | Mary |
| Danny Wells | Dick Jennings |
Coincidence, divine intervention and fate link several people on an intense day which becomes a moral odyssey.
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