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| Tyler Perry | Madea/Brian/Joe |
| Blair Underwood | Carlos |
| Lynn Whitfield | Victoria |
| Boris Kodjoe | Frankie |
| Maya Angelou | May |
| Jenifer Lewis | Milay Jenay Lori |
| Keke Palmer | Nikki |
| Cicely Tyson | Myrtle |
| Rochelle Aytes | Lisa |
| Henry Simmons | Issac |
| Lisa Arrindell Anderson | Vanessa |
| Tangi Miller | Donna |
Southern matriarch Madea has a lot on her plate. Her nieces have relationship troubles, and Madea has just been ordered by the court to become the guardian of a rebellious teenager named Nikki. Madea must keep the peace and keep her family together while simultaneously planning her clan's reunion.
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