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| Rick Moranis | Seymour Krelborn |
| Ellen Greene | Audrey |
| Steve Martin | Orin Scrivello, D.D.S. |
| Vincent Gardenia | Mr. Mushnik |
| Tichina Arnold | Crystal |
| Tisha Campbell | Chiffon |
| Michelle Weeks | Ronette |
| James Belushi | Patrick Martin |
| John Candy | Wink Wilkinson |
| Christopher Guest | The First Customer |
| Bill Murray | Arthur Denton |
A clerk in a Skid Row flower shop feeds people to Audrey II, his talking plant from outer space.
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