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| Adam Sandler | Nicky |
| Patricia Arquette | Valerie |
| Harvey Keitel | Dad |
| Rhys Ifans | Adrian |
| Tommy ``Tiny'' Lister Jr. | Cassius |
| Robert Smigel | Beefy |
| Allen Covert | Todd |
| Peter Dante | Peter |
| Jonathan Loughran | John |
| Blake Clark | Jimmy The Demon |
| Rodney Dangerfield | Lucifer |
| Kevin Nealon | Gatekeeper |
| Reese Witherspoon | Holly |
| Dana Carvey | Referee |
| Jon Lovitz | Peeper |
| Quentin Tarantino | Deacon |
| Michael McKean | Chief of Police |
| Carl Weathers | Chubbs |
| Rob Schneider | The Townie |
| Clint Howard | Nipples |
| Lewis Arquette | Cardinal |
| George Wallace | Mayor Randolph |
| Henry Winkler | Himself |
| Ozzy Osbourne | Himself |
| Bill Walton | Himself |
| Regis Philbin | Himself |
The youngest son of Satan must go to New York City and bring back his brothers, whose absence is wreaking havoc in hell.
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