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| Eddie Murphy | Rayford Gibson |
| Martin Lawrence | Claude Banks |
| Obba Babatunde | Willie Long |
| Ned Beatty | Dexter Wilkins |
| Bernie Mac | Jangle Leg |
| Miguel A. Núñez. Jr. | Biscuit |
| Clarence Williams III | Winston Hancock |
| Bokeem Woodbine | Can't Get Right |
| Michael 'Bear' Taliferro | |
| Barry Shabaka Henley | Pokerface |
| Brent Jennings | Hoppin' Bob |
| Guy Torry | Radio |
| Lisa Nicole Carson | Sylvia |
| O'Neal Compton | Superintendant Abernathy |
| Poppy Montgomery | Older Mae Rose |
| Ned Vaughn | Young Sheriff Pike |
| R. Lee Ermey | Older Sheriff Pike |
| Nick Cassavetes | Sergeant Dillard |
| Anthony Anderson | Cookie |
| Noah Emmerich | Stan Blocker |
| Rick James | Spanky Johnson |
Wrongly convicted of murder, two men become close friends during decades in a Mississippi penitentiary.
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