| Mel Gibson | Martin Riggs |
| Danny Glover | Roger Murtaugh |
| Joe Pesci | Leo Getz |
| Rene Russo | Lorna Cole |
| Chris Rock | Detective Lee Butters |
| Jet Li | Wah Sing Ku |
| Steve Kahan | Captain Ed Murphy |
| Kim Chan | Benny 'Uncle Benny' Chan |
| Darlene Love | Trish Murtaugh |
| Traci Wolfe | Rianne Murtaugh Butters |
| Eddy Ko | Hong (Chinese refugee) |
| Steven Lam | Ping |
| Richard Libertini | Rabbi Gelb |
Los Angeles police partners take on members of a Chinese triad who are smuggling families from the mainland.
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