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| Larry the Cable Guy | Larry |
| Iris Bahr | Amy Butlin |
| Bruce Bruce | Big Shug |
| Joanna Cassidy | Lily Micelli |
| Brooke Dillman | Brenda |
| Tony Hale | Jack Dobbs |
| David Koechner | Donnie |
| Lisa Lampanelli | Jane's Mom |
| Megyn Price | Jane Whitley |
| Tom Wilson | Bart Tatlock |
| Joe Pantoliano | Mayor Gunn |
| Tom Hillman | Tad |
| Eric Esteban | Sakamoto |
| Jerry Mathers | Himself |
Larry, an uncouth health inspector, teams up with a straight-laced rookie partner to investigate an outbreak of food poisoning at the city's swankiest eateries, but when his unorthodox methods cost him his job, he must go under cover to make dining out safe again.
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