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| Matthew Modine | Mel |
| Gina Gershon | Ginger |
| Christy Scott Cashman | Diana |
| Isiah Whitlock Jr. | Freddie |
| Kevin J. O'Connor | Harry |
| Fisher Stevens | Bruce |
| Gloria Reuben | Mindy |
| Eddie Kaye Thomas | Sean |
| Tamara Whatley | Beth |
| Tarajia Morrell | Sheila |
| Malachy McCourt | Robert |
| Revina Delmars | Isabelle |
| Ewa Da Cruz | Inga |
New York City musician Mel is a womanizer with serious commitment issues. Nonetheless, he tries for some intimacy by moving in with his girlfriend and subletting his apartment to an attractive biologist named Ginger . But, after living with his girlfriend goes awry, Mel negotiates to come back and live with Ginger. Although they argue at first, they eventually become close friends. These new circumstances puts Mel's Casanova ethos to the test.
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