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| Amy Adams | Ashley |
| Embeth Davidtz | Madeleine |
| Ben McKenzie | Johnny Johnsten |
| Alessandro Nivola | George |
| Frank Hoyt Taylor | David Wark |
| Celia Weston | Peg |
| Scott Wilson | Eugene |
| Amy Barefoot | Kitty, friend at shower |
| Annette Beatty | Dr. Beatty |
| Matt Besser | Scout who goes in |
| Beth Bostic | Lucille the neighbor |
| Alicia van Couvering | Bernadette |
On the way to meet with an independent artist in the South, newlywed art dealer Madeleine is convinced by her husband, George, that they should stop to meet his family in North Carolina. Madeleine's affluent lifestyle clashes with the family, but she befriends George's wide-eyed and pregnant sister-in-law, Ashley, who is nearing her due date. Through the family, Madeleine gains greater insight into George's character.
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