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| Denzel Washington | John Q. Archibald |
| Robert Duvall | Grimes |
| James Woods | Dr. Turner |
| Anne Heche | Rebecca Payne |
| Eddie Griffin | Lester |
| Kimberly Elise | Denise Archibald |
| Shawn Hatosy | Mitch |
| Ray Liotta | Monroe |
| Daniel E. Smith | Michael 'Mike' Archibald |
| David Thornton | Jimmy Palumbo |
| Ethan Suplee | Max |
| Kevin Connolly | Steve Maguire |
| Paul Johansson | Tuck Lampley |
| Heather Wahlquist | Julie |
| Troy Beyer | Miriam |
| Obba Babatunde | Sgt. Moody |
| Troy Winbush | Steve |
| Laura Harring | Gina Palumbo |
| Larissa Laskin | Dr. Klein |
| Dina Waters | Debby Utley |
| Martha Chaves | Rosa Gonzales |
A desperate man takes hostages at a hospital in order to force doctors to save his dying son.
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