|Ice Cube||James "Desolation" Williams|
|Natasha Henstridge||Melanie Ballard|
|Jason Statham||Jericho Butler|
|Clea DuVall||Bashira Kincaid|
|Pam Grier||Helena Braddock|
|Richard Cetrone||Big Daddy Mars|
|Liam White||Michael Descanso|
Long inhabited by human settlers, the Red Planet has become the manifest destiny of an over-populated Earth. Nearly 640,000 people now live and work all over Mars, mining the planet for its abundant natural resources. But one of those mining operations has uncovered a deadly mother lode: a long-dormant Martian civilization whose warriors are systematically taking over the bodies of human intruders.