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| Robin Williams | Jack Powell |
| Diane Lane | Karen Powell |
| Jennifer Lopez | Miss Marquez |
| Brian Kerwin | Brian Powell |
| Fran Drescher | Dolores 'D.D.' Durante |
| Bill Cosby | Lawrence Woodruff |
| Michael McKean | Paulie |
| Don Novello | Bartender |
| Allan Rich | Dr. Benfante |
| Adam Zolotin | Louis 'Louie/Lou' Durante |
| Todd Bosley | Eddie |
| Seth Smith | John-John |
| Mario Yedidia | George |
| Jeremy Lelliott | Johnny Duffer |
| Rickey D'Shon Collins | Eric |
| Hugo Hernandez | Victor |
After an unusually short pregnancy, Karen Powell gives birth to a baby boy whose body ages much faster than the normal rate. With her husband, Brian, Karen raises their son, Jack, who appears to be a 40-year-old man when he is only 10. Though Jack ages rapidly physically, he is mentally and emotionally still a young boy, which causes him considerable difficulty. Eventually, Jack gains the support of his peers, which helps him live a fuller life.
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