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| Boris Karloff | General Nikolas Pherides |
| Ellen Drew | Thea |
| Marc Cramer | Oliver Davis |
| Katherine Emery | Mrs. Mary St. Aubyn |
| Helene Thimig | Madame Kyra |
| Alan Napier | St. Aubyn |
| Jason Robards Sr. | Albrecht |
| Skelton Knaggs | Andrew Robbins |
| Sherry Hall | Colonel Kobestes |
| Ernest Dorian | Dr. Drossos |
| Erick Hanson | Officer |
Gen. Nikolas Pherides takes leave from the 1912 Balkan War to visit a small island in Greece, where his wife is buried. While there, a plague breaks out -- and along with an American reporter and several other travelers, Pherides is forced to stay when quarantine is declared. Soon, locals and foreigners alike succumb to the influence of Madame Kyra, who accuses a nurse of being a vampire and the true cause of the recent deaths.
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