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| Meg Ryan | Frannie |
| Mark Ruffalo | Detective Malloy |
| Jennifer Jason Leigh | Pauline |
| Nick Damici | Detective Rodriguez |
| Sharrieff Pugh | Cornelius Webb |
| Sunrise Coigney | Frannie's Young Mother |
| Micheal Nuccio | Frannie's Young Father |
| Alison Nega | Young Father's Fiancee |
| Dominick Aries | Attentive Husband |
| Susan Gardner | Perfect Wife |
| Heather Litteer | Angela Sands |
| Daniel T. Booth | Red Turtle Bartender |
| Yaani King | Frannie's Student |
| Frank Harts | Frannie's Student |
| Sebastian Sozzi | Frannie's Student |
| Zach Wegner | Frannie's Student |
| Patrice O'Neal | Hector |
An English teacher has an affair with a detective, though she suspects him of murdering a woman.
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