|John Cleese||Dr. Glickenstein|
|Jay Leno||King Malbert|
|Eddie Izzard||Dr. Schadenfreude|
|Arsenio Hall||Carl Crystal|
|Christian Slater||Dr. Schadenfreude's Igor|
Lab assistant Igor dreams of becoming a mad scientist like his master, Dr. Glickenstein. When the doctor runs afoul of his own invention, Igor seizes the chance. With the help of his friends Scamper and Brain, Igor plans to win the kingdom's annual science fair by building the most-evil monster ever. The problem is that Eve, as the monster is called, is sweeter than sugar and would rather be an actress.