| Macaulay Culkin | Kevin McCallister |
| Joe Pesci | Harry Lime |
| Daniel Stern | Marv Merchants |
| Catherine O'Hara | Kate McCallister |
| John Heard | Peter McCallister |
| Devin Ratray | Buzz McCallister |
| Tim Curry | Mr. Hector, Hotel Concierge |
| Brenda Fricker | Central Park Pigeon Woman |
| Eddie Bracken | Mr. E.F. Duncan, Owner Duncan's Toy Chest |
| Gerry Bamman | Uncle Frank McCallister |
Once again left behind by his family, the boy hero lands in Manhattan and battles two burglars he faced before.
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